Antiproliferation effects of nanophytosome-loaded phenolic compounds from fruit of Juniperus polycarpos against breast cancer in mice model: synthesis, characterization and therapeutic effects

Abstract Background This research was performed to synthesize nanophytosome-loaded high phenolic fraction (HPF) from Juniperus polycarpos fruit extract and investigate its antiproliferation effects against breast cancer in mice model. Results The HPF synthesized. trial conducted determine the possible toxic of synthesized nanophytosomes. anticancer, pro-apoptotic, antioxidative activities nanophytosomes were determined. had a spherical structure with size 176 nm polydispersity index coefficient 0.24. vivo study manifested that significantly improved weight gain food intake compared negative control group ( p < 0.05). enhanced expression bax (3.4-fold) caspase-3 (2.7-fold) genes, but reduced bcl2 (3.6-fold) gene tumor cells. average decreased treated GPX (2.3-fold) SOD antioxidants liver supplemented developed did not show toxicity on normal Conclusion Our results indicated might be potential anticancer agent for treatment.